It is caused by complete or comparative lack of insulin which leads to an abnormality in the carbohydrate, fat and protein metabolism. Insulin resistance leads to both high blood pressure and dyslipidemia. One has to appreciate that the reason the insulin levels are high is that there is insulin resistance. There is no question that there is an association between insulin levels and CAD. This is a major question. But a low carb diet with normal calories is a high fat diet, and doctors have been brainwashed to believe that high fat/low carb diets cause heart disease. It contains high fat and low enzymes. I think the the high insulin index of very low carbohydrate foods (meats, eggs) can be attributed to the fact that the Insulin Index is calculated using the carbohydrate content of the food in the denominator. Technically, although the Abbott Freestyle Libre 2 is often referred to as a CGM, it is in fact a “flash glucose monitoring system” as it relies upon the user to scan the sensor in order to receive the glucose readings stored in the sensor. I rely upon calibrations to keep the Dexcom readings accurate. It alerts me to impending lows which I love, but it seemingly never returns to normal readings after treating a low, it keeps alarming and alarming unless I calibrate the dexcom g6 sensor app to force it to show a reading that accurately reflects a normalized fingerstick reading, effectively forcing it to do so, which sucks.
Under normal conditions the network is balanced. In healthy people who can compensate for the insulin resistance, you can have a higher insulin level and still have a normal glucose level. I thank the IRS for reclassifying certain medical care services received and items purchased, including prescription drugs and a few medical devices for certain chronic conditions which are now be re-classified as “preventive care” for people living with chronic conditions. Until there are changes to our health care system and/or public health initiatives that make intense lifestyle modifications more reasonable, pharmacotherapy to prevent diabetes has an important role. There are some other important things to know about causes of diabetes are excess intake of oil and sugar, hereditary and genetics factors, increased cholesterol level, over weight, stress, sedentary lifestyle. There have been several intriguing studies recently that suggest that an imbalance between the alpha cells that secrete glucagon, the hormone that raises blood sugar, and the insulin-secreting beta cells may play a part in causing diabetes.
FYI, there have been several studies done on dairy and I suggest you guys to check them out. Most of these studies were done in nondiabetic populations. A number of epidemiological studies going back to the 1970s and continuing even now demonstrated that the higher the circulating insulin levels, the higher the likelihood of coronary artery disease (CAD). Even without insulin there is a huge glucose uptake. The reality is I will always trust a fingerstick reading of actual plasma blood glucose more than a reading from a CGM which isn’t a blood glucose reading, but a correlation to blood glucose based on molecules found in interstitial fluid. Maybe the G7 will fix that and maybe it won’t. And it always will. My guess is that will mean a big price increase to the device, and the added value seems less thrilling to me. The reality is with my current healthcare plan, whenever I pick-up my Dexcom G6 Sensors, my cost has steadily been $35 each month, which is well below the actual retail price of $350.00 for a package of three Dexcom G6 sensors sold at CVS. I, like more than 55% of all Americans, have a high-deductible insurance plan which means they’re forced to pay the bloated higher price for Dexcom’s G7 sensors out-of-pocket, at least until mid-year when many usually satisfy the annual deductible.
In fact, Abbott’s Libre 2 sensors sell for about a third less than Dexcom’s (or Medtronic’s) sensors do, and they last for 14-days (although likely could work for an even longer period of time if the adhesive lasted) compared to only 10-days associated with Dexcom’s G6 system. Among the new features and supposed improvements will be a reduction in the sensor warm-up time from a lengthy 2 hours (on the G6) to just a half-hour (on the G7), and the company will also be making its sensors and transmitters all-in-one, with the automated inserter device handling regular replacements as the G6 does. In the presence of low insulin, the hormones glucagon from the pancreas or epinephrine from the adrenal glands will stimulate the activity of hormone-sensitive lipase (HSL). But that’s because insulin is easy to measure, and so epidemiologists measure insulin, not insulin resistance, and may conclude erroneously that insulin is responsible for the increased CAD. The culprit is the insulin resistance, not hyperinsulinemia. Hyperinsulinemia is a compensatory mechanism that is not itself responsible for the increased CAD. The body’s compensatory mechanism to overcome the insulin resistance is to raise the circulating insulin level.